Peutz–Jeghers syndrome with concurrent lobular endocervical glandular hyperplasia and sex cord tumor with annular tubules: a case report

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Peutz–Jeghers syndrome (PJS) is an autosomal dominant disorder linked to mucocutaneous pigmentation and increased cancer risk.
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A 25-year-old woman with PJS presented with cervical and ovarian masses, diagnosed as lobular endocervical glandular hyperplasia and sex-cord tumor with annular tubules.
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Histopathological examination revealed lobular endocervical glandular hyperplasia as a potential precursor lesion for malignancy.
4

The case highlights the need for regular gynecological surveillance in women with PJS due to the risk of associated gynecological tumors.
5

Genetic testing confirmed a germline mutation in the STK11 gene, consistent with the diagnosis of Peutz–Jeghers syndrome.

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