Associations between prevalent unhealthy lifestyles and the gut microbiota: a comprehensive multi-database bibliometric analysis of pathogenic mechanisms and clinical trajectories

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Unhealthy lifestyles contribute to gut microbiota dysbiosis through inflammatory and immune-related pathways.
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The study analyzed 5,380 records from 2001 to 2026, focusing on smoking, alcohol, sleep disorders, sedentary behavior, and high-sugar diets.
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China and the United States are the leading contributors to research on lifestyle-microbiome interactions.
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Core themes identified include inflammation, oxidative stress, obesity, and metabolic dysfunction as mediators of microbial dysbiosis.
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The findings emphasize the importance of targeted lifestyle interventions for preserving gut microbiota and improving gastrointestinal health.

Frontiers In Medicine

by Xiao-Jie Zhou, Jun-Lei Chen, Chen-Feng Hu, Zhang-Kai Li, Hong-Bo Zheng, Tu-Nan Ding, Yan Chen, Yan Zhu, Jia-Ni Li, Qiang Fu, Yin Fu
May 12, 2026

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