Utilizing Intra- and Peritumoral Radiomics to Assess Ambiguous HER2 Status in Breast Cancer via Contrast-Enhanced Mammography - Takeaways - MDSpire

Utilizing Intra- and Peritumoral Radiomics to Assess Ambiguous HER2 Status in Breast Cancer via Contrast-Enhanced Mammography

  • By

  • Cong Xu

  • Juan Qiu

  • Shijie Zhang

  • Yuqian Chen

  • Xiaodong Wang

  • Haicheng Zhang

  • Qi Wang

  • Tongpeng Chu

  • Ziyin Li

  • Peng Lu

  • Haizhu Xie

  • Heng Ma

  • Nina Qu

  • Ning Mao

  • Jing Liu

  • Runpeng Chen

  • Jing Gao

  • April 29, 2026

  • 0 min

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  • 1

    The study evaluated the equivocal HER2 (IHC 2+) status in breast cancer using intra- and peritumoral radiomics features from contrast-enhanced mammography.

  • 2

    A total of 131 breast cancer patients were enrolled, divided into training, internal test, and prospective test cohorts for model evaluation.

  • 3

    The nomogram incorporating intratumoral and peritumoral signatures achieved optimal predictive performance with AUCs of 0.893 and 0.840 in internal and prospective cohorts, respectively.

  • 4

    Contrast-enhanced mammography (CEM) offers a non-invasive method to assess HER2 status, potentially reducing reliance on time-consuming FISH testing.

  • 5

    The study highlights the clinical applicability of radiomics in predicting HER2 status, bridging the gap between advanced imaging techniques and routine clinical practice.

Original Source(s)

Utilizing Intra- and Peritumoral Radiomics to Assess Ambiguous HER2 Status in Breast Cancer via Contrast-Enhanced Mammography

  • by Cong Xu, Juan Qiu, Shijie Zhang, Yuqian Chen, Xiaodong Wang, Haicheng Zhang, Qi Wang, Tongpeng Chu, Ziyin Li, Peng Lu, Haizhu Xie, Heng Ma, Nina Qu, Ning Mao, Jing Liu, Runpeng Chen, Jing Gao

  • April 29, 2026

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