Long-term Sequelae in Ebola Virus Disease Survivors Receiving Anti-Ebola Virus Therapies in the Democratic Republic of the Congo: A Prospective Cohort Study - Takeaways - MDSpire

Long-term Sequelae in Ebola Virus Disease Survivors Receiving Anti-Ebola Virus Therapies in the Democratic Republic of the Congo: A Prospective Cohort Study

  • By

  • Angèle Dilu-Keti

  • Tamara Tovar-Sanchez

  • Benjamin Cuer

  • Antoine Nkuba-Ndaye

  • Daniel Mukadi-Bamuleka

  • Eric Panzi-Kalunda

  • Richard Kitenge-Omasumbu

  • Junior Bulabula-Penge

  • Fabrice Mambu-Mbika

  • Placide Mbala-Kingebeni

  • Ahidjo Ayouba

  • Jean-Jacques Muyembe-Tamfum

  • Jean-François Etard

  • Faustin Chenge

  • Eric Delaporte

  • Steve Ahuka-Mundeke

  • for the ‘Les Vainqueurs d’Ebola’ study group

  • Steve Ahuka-Mundeke

  • Ahidjo Ayouba

  • Nella Bisento-Ngafa

  • Julie Boullin

  • Junior Bulabula-Penge

  • Bernice Danga-Yema

  • Eric Delaporte

  • Angèle Dilu Keti

  • François Edidi-Atani

  • Grâce Ekoko

  • Benjamin Hamzé

  • Grâce Hangi

  • Gabriel Kambaba Lungeni

  • Neema Kahindo Barumawaki

  • Fey Kahonga

  • John Kakule Muzombo

  • Callixte Kakule-Sadiki

  • Guillaume Kambale-Kasyamboko

  • Vianey Kambale Kombi

  • Nelson Kambale-Sivihwa

  • Philemon Kambale Tsongo

  • Sahani Kanyere Lwanzo

  • Victoire Katembo Thasi

  • Suzanne Kavira Muhasa

  • Sheila Kavira-Muhesi

  • Eli Kavoyo-Mbayayi

  • Eddy Kinganda-Lusamaki

  • Richard Kitenge Omasumbu

  • Divine Kitsa-Mutsumbirwa

  • Rebecca Kyakimwa Vahaviraki

  • Audrey Lacroix

  • Achilla Luwawu Sadila

  • Robert Makasi Menge

  • Fabrice Mambu-Mbika

  • Rachel Masika Kihigo

  • Immaculée Matimbiya Vihanba

  • Meris Matondo-Kuamfumu

  • Placide Mbala Kingebeni

  • Fyfy Mbelu Matulu

  • Daniel Mukadi-Bamuleka

  • Noella Mulopo-Mukanya

  • Elia Mumbere-Kalemekwa

  • Serge Mumbere Kavalami

  • Jacques Mumbere Mutegana

  • Skoda Mumbere Muyisa

  • Fiz Mussa Bahizi

  • Jean-Jacques Muyembe-Tamfum

  • Antoine Nkuba-Ndaye

  • César Omeonga Kelenda

  • Jeannot Paluku Nzira

  • Defao Paluku-Salambongo

  • Eric Panzi-Kalunda

  • Martine Peeters

  • Raphaël Pelloquin

  • Guillaume Thaurignac

  • Tamara Tovar-Sanchez

  • July 31, 2025

  • 0 min

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  • 1

    The study analyzed long-term outcomes in 750 Ebola survivors treated with advanced therapies during the 2018-2020 outbreak in the DRC.

  • 2

    Of the survivors, 86.7% experienced post-Ebola sequelae, with neurologic issues being the most common at 61.7%.

  • 3

    Neurologic sequelae were more frequent in survivors treated with REGN-EB3 compared to those treated with remdesivir.

  • 4

    Musculoskeletal sequelae were linked to older age, ZMapp treatment, and acute-phase hemorrhagic symptoms.

  • 5

    The findings emphasize the need for targeted long-term care to manage persistent post-Ebola sequelae in survivors.

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