LOXL1, THY1, and TYMS define an annotation-derived hemoglobin-associated immunotranscriptomic signature in osteoarthritis cartilage - Takeaways - MDSpire
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An Immunotranscriptomic Signature Linked to Hemoglobin in Osteoarthritis Cartilage Identified by LOXL1, THY1, and TYMS Markers

  • By

  • Xin Zhang

  • Zhaochen Ye

  • Zheng Qin

  • Yizhe Li

  • Zhilong Jing

  • Dawei Yang

  • July 9, 2026

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  • 1

    The study identifies LOXL1, THY1, and TYMS as Hb-associated biomarkers in osteoarthritis cartilage through transcriptomic analysis.

  • 2

    These hub genes were consistently upregulated in osteoarthritis cartilage across multiple independent datasets.

  • 3

    Immune profiling revealed an immune-activated state in osteoarthritis cartilage, with increased macrophage signals and reduced resting NK cells.

  • 4

    The expression of LOXL1, THY1, and TYMS correlated positively with macrophage and activated T-cell signatures.

  • 5

    A nomogram based on these genes demonstrated high discriminative performance, achieving an AUC of 0.974 in the training cohort.

Original Source(s)

LOXL1, THY1, and TYMS define an annotation-derived hemoglobin-associated immunotranscriptomic signature in osteoarthritis cartilage

  • by Xin Zhang, Zhaochen Ye, Zheng Qin, Yizhe Li, Zhilong Jing, Dawei Yang

  • July 9, 2026

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