Case Report: Identification of rare H3-3A p.G35W variant in a case of adolescent tectal plate low-grade glioma - Takeaways - MDSpire

Case Report: Identification of rare H3-3A p.G35W variant in a case of adolescent tectal plate low-grade glioma

  • By

  • Andy Ung

  • Vanesa M. Tomatis

  • Esther Quick

  • Laveniya Satgunaseelan

  • Ema Knight

  • Chrisovalantis Tsimiklis

  • Elyse C Page

  • Jordan R. Hansford

  • Annika R. Mascarenhas

  • April 30, 2026

  • 0 min

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  • 1

    An adolescent with low-grade glioma underwent a stereotactic endoscopic biopsy, revealing a pilocytic astrocytoma.

  • 2

    The rare H3-3A p.G35W mutation was identified, previously linked to giant cell tumors and not characterized in tectal plate gliomas.

  • 3

    Methylation and targeted sequencing were performed to understand the tumor's molecular profile and potential behavior.

  • 4

    Tectal plate gliomas are rare, accounting for less than 5% of pediatric brainstem tumors, with a generally indolent natural history.

  • 5

    Management typically focuses on symptomatic treatment for complications like obstructive hydrocephalus rather than direct tumor therapy.

Original Source(s)

Case Report: Identification of rare H3-3A p.G35W variant in a case of adolescent tectal plate low-grade glioma

  • by Andy Ung, Vanesa M. Tomatis, Esther Quick, Laveniya Satgunaseelan, Ema Knight, Chrisovalantis Tsimiklis, Elyse C Page, Jordan R. Hansford, Annika R. Mascarenhas

  • April 30, 2026

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