Giant solid pseudopapillary neoplasm of the pancreas in an adolescent girl: a case report with narrative review - Takeaways - MDSpire

Giant solid pseudopapillary neoplasm of the pancreas in an adolescent girl: a case report with narrative review

  • By

  • Hang Zhou

  • Jinqin Zha

  • Yu Yang

  • Yiwei Hou

  • Chongyuan Chen

  • Mingzheng Hu

  • Rongchun Xing

  • July 15, 2026

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  • 1

    Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor with low malignant potential, predominantly affecting adolescent girls and young women.

  • 2

    A 15-year-old girl presented with acute abdominal pain and imaging revealed a giant mixed solid-cystic mass in the pancreatic body and tail.

  • 3

    The patient underwent laparoscopic distal pancreatectomy with splenectomy, and histopathology confirmed SPN with negative margins and no nodal metastasis.

  • 4

    Immunohistochemistry showed positivity for beta-catenin and CD10, supporting the diagnosis of solid pseudopapillary neoplasm.

  • 5

    Postoperative follow-up indicated an uneventful recovery with no evidence of recurrence, emphasizing the importance of surgical strategy in giant SPN.

Original Source(s)

Giant solid pseudopapillary neoplasm of the pancreas in an adolescent girl: a case report with narrative review

  • by Hang Zhou, Jinqin Zha, Yu Yang, Yiwei Hou, Chongyuan Chen, Mingzheng Hu, Rongchun Xing

  • July 15, 2026

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