Early postoperative orthostatic intolerance: pathophysiology and clinical implications - Takeaways - MDSpire

Early postoperative orthostatic intolerance: pathophysiology and clinical implications

  • By

  • Girish P Joshi

  • Dileep N Lobo

  • Henrik Kehlet

  • June 6, 2025

  • 0 min

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  • 1

    Early postoperative ambulation is crucial for recovery, preventing complications like pneumonia and deep-vein thrombosis.

  • 2

    Postoperative orthostatic intolerance can hinder ambulation and is often under-diagnosed, despite optimized ERAS pathways.

  • 3

    The pathophysiology of orthostatic intolerance involves dysregulated autonomic responses and inadequate heart rate adjustments.

  • 4

    Opioids can exacerbate orthostatic intolerance by impairing cardiovascular responses during postural changes.

  • 5

    Preoperative risk identification and ERAS pathways may help mitigate orthostatic intolerance and promote early mobilization.

Original Source(s)

Early postoperative orthostatic intolerance: pathophysiology and clinical implications

  • by Girish P Joshi, Dileep N Lobo, Henrik Kehlet

  • June 6, 2025

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