Implications of different SOFA score variants for outcome prediction in emergency department patients with an infection: a multicenter cohort study - Takeaways - MDSpire
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Comparing SOFA Score Variants for Outcome Prediction in Emergency Department Patients With Infection: A Multicenter Cohort Study

  • By

  • Tamar J. van der Aart

  • Carolina Hincapié-Osorno

  • Isaac Santiago Arango-Gil

  • Konstantin Föhse

  • Jacobien J Hoogerwerf

  • Fabián Jaimes

  • Jacqueline Koeze

  • Marco van Londen

  • Jan C. ter Maaten

  • Jaap ten Oever

  • Renée A.M. Tuinte

  • Carlos E. Vallejo

  • Raymond J. van Wijk

  • Hjalmar R. Bouma

  • Douwe F. Postma

  • October 20, 2026

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  • 1

    This post hoc multicenter analysis compares 7 SOFA variants for predicting the composite outcome of all-cause in-hospital mortality and/or intensive care unit (ICU) admission among emergency department (ED) adults with confirmed infection.

  • 2

    The analysis includes 2036 adults from the Acutelines, Sepsis 2-3, and SUSPECT cohorts at 2 hospitals in the Netherlands.

  • 3

    SOFA scores generally use the worst clinical and laboratory values recorded within 24 hours after ED presentation, regardless of whether patients are in the ED, ward, or ICU.

  • 4

    The variants differ in their handling of missing data, adjustment for baseline organ dysfunction, automated calculation, or simplification of the original score.

  • 5

    Urine output is excluded where applicable. In the primary analysis, any norepinephrine use receives 4 points because missing pump-dose recordings prevent reliable distinction between low-dose and high-dose administration.

Original Source(s)

Implications of different SOFA score variants for outcome prediction in emergency department patients with an infection: a multicenter cohort study

  • by Tamar J. van der Aart, Carolina Hincapié-Osorno, Isaac Santiago Arango-Gil, Konstantin Föhse, Jacobien J Hoogerwerf, Fabián Jaimes, Jacqueline Koeze, Marco van Londen, Jan C. ter Maaten, Jaap ten Oever, Renée A.M. Tuinte, Carlos E. Vallejo, Raymond J. van Wijk, Hjalmar R. Bouma, Douwe F. Postma

  • October 20, 2026

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