Evaluation of a strain Long human respiratory syncytial virus with M2–2 gene deletion in intranasally vaccinated BALB/c mice - Takeaways - MDSpire

Evaluation of a strain Long human respiratory syncytial virus with M2–2 gene deletion in intranasally vaccinated BALB/c mice

  • By

  • Ri-gan Shu

  • Jie Jun

  • Yun-xuan Zheng

  • Dan-ning Yue

  • Hao Hu

  • Hua-wei Xu

  • Xiao-lei Zhao

  • Hong-ru Wang

  • Xi-man Liu

  • Yi-peng Zhang

  • He Wang

  • Jie-mei Yu

  • Yan-peng Zheng

  • Xiang-lei Peng

  • Yuan-hui Fu

  • Jin-sheng He

  • June 8, 2026

  • 0 min

Share

  • 1

    RSV is a major cause of lower respiratory tract illness, especially in infants and the elderly, with no licensed vaccines for children under 6 months.

  • 2

    Live-attenuated vaccines (LAVs) targeting RSV have been developed, focusing on strains with M2-2 gene deletions to enhance safety and immunogenicity.

  • 3

    In BALB/c mice, the RLΔM2-2 strain showed lower lung viral loads and less body weight loss compared to other strains after infection.

  • 4

    Intranasal immunization with RLΔM2-2 induced strong immune responses, including neutralizing antibodies and CD8+ T-cell responses.

  • 5

    The study supports the M2-2 deletion strategy as a promising approach for developing safe and effective RSV vaccines for infants.

Original Source(s)

Evaluation of a strain Long human respiratory syncytial virus with M2–2 gene deletion in intranasally vaccinated BALB/c mice

  • by Ri-gan Shu, Jie Jun, Yun-xuan Zheng, Dan-ning Yue, Hao Hu, Hua-wei Xu, Xiao-lei Zhao, Hong-ru Wang, Xi-man Liu, Yi-peng Zhang, He Wang, Jie-mei Yu, Yan-peng Zheng, Xiang-lei Peng, Yuan-hui Fu, Jin-sheng He

  • June 8, 2026

Related Content

How the Amish think about vaccines, health care costs, and much more

Human Papillomavirus Vaccine Discourse and Sentiment on Reddit Before and After COVID-19: Mixed Methods Retrospective Cross-Sectional Study

Systems biology approach unveils the cellular and molecular mechanisms of formalin-inactivated whole cell vaccine-induced protective immunity against Coxiella burnetii infection in mice