Prognostic significance of interstitial fibrosis and tubular atrophy in biopsy-proven diabetic kidney disease: a single-center retrospective cohort study - Takeaways - MDSpire

Prognostic significance of interstitial fibrosis and tubular atrophy in biopsy-proven diabetic kidney disease: a single-center retrospective cohort study

  • By

  • Rui Zhang

  • Mingyan Wu

  • Hui Yang

  • Xingyan Zhou

  • Ziwei Guo

  • Haiyan Yu

  • Wenyu Song

  • Yi Bao

  • Yuxing Yang

  • Rui Yan

  • July 8, 2026

  • 0 min

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  • 1

    The study evaluated the prognostic value of interstitial fibrosis and tubular atrophy (IFTA) in biopsy-confirmed diabetic kidney disease (DKD).

  • 2

    A total of 164 patients with type 2 diabetes and biopsy-confirmed DKD were followed for a median of 38 months in this retrospective cohort study.

  • 3

    IFTA score 2/3 was associated with a higher risk of reaching the composite kidney endpoint compared to IFTA score 1 (HR 3.96, P = 0.001).

  • 4

    Higher 24-hour proteinuria and lower serum calcium levels were independently linked to poor kidney outcomes in patients with DKD.

  • 5

    The findings suggest that IFTA severity, along with proteinuria and serum calcium, may be important predictors of kidney survival in DKD.

Original Source(s)

Prognostic significance of interstitial fibrosis and tubular atrophy in biopsy-proven diabetic kidney disease: a single-center retrospective cohort study

  • by Rui Zhang, Mingyan Wu, Hui Yang, Xingyan Zhou, Ziwei Guo, Haiyan Yu, Wenyu Song, Yi Bao, Yuxing Yang, Rui Yan

  • July 8, 2026

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