A transdiagnostic niacin flushing biomarker with disorder-specific multivariate relationships in adolescent unipolar and bipolar depression - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

A Biomarker for Niacin-Induced Flushing Exhibiting Disorder-Specific Multivariate Associations in Adolescent Unipolar and Bipolar Depression

  • By

  • Mengyao Feng

  • Jinxin He

  • Qi Wen

  • Jie Yao

  • Yuting Zeng

  • Yupan Tan

  • Hongjie Li

  • Yigang Wang

  • Guanghai Wang

  • Li Dong

  • Xia Sun

  • Yuanyuan Zhang

  • Shuxian Yin

  • Huan Peng

  • Maolin Hu

  • Xiaofen Zong

  • January 12, 2026

Share

  • 1

    The study investigates niacin skin flushing response (NSFR) as a potential biomarker for unipolar and bipolar depression in adolescents.

  • 2

    A total of 315 adolescents aged 10–19 were recruited, including patients with unipolar depression, bipolar disorder, and healthy controls.

  • 3

    The research aims to confirm similar NSFR attenuation in both mood disorders and evaluate its effectiveness in distinguishing patients from healthy controls.

  • 4

    Sparse canonical correlation analysis will explore disorder-specific multivariate relationships between NSFR features and clinical behavior.

  • 5

    The findings may provide insights into shared biological deficits and distinct clinical presentations of unipolar and bipolar depression in adolescents.

Original Source(s)

A transdiagnostic niacin flushing biomarker with disorder-specific multivariate relationships in adolescent unipolar and bipolar depression

  • by Mengyao Feng, Jinxin He, Qi Wen, Jie Yao, Yuting Zeng, Yupan Tan, Hongjie Li, Yigang Wang, Guanghai Wang, Li Dong, Xia Sun, Yuanyuan Zhang, Shuxian Yin, Huan Peng, Maolin Hu, Xiaofen Zong

  • January 12, 2026

Related Content

Data-Entry Error in Meta-Analysis of Suicide Prevention in Children and Adolescents

  • September 1, 2026

Communicating with families during armed conflict: when healthcare systems fracture but phones remain

Availability of Telehealth Services for Children at Mental Health Treatment Facilities