Efficacy and Safety Comparison of Antibacterial Treatments for Severe Infections Caused by Stenotrophomonas maltophilia: A Systematic Review and Network Meta-Analysis

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Stenotrophomonas maltophilia is an opportunistic pathogen associated with severe infections, particularly among critically ill patients in intensive care units.
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TMP-SMX is the conventional treatment for S maltophilia, but resistance and dose-dependent adverse events can limit its clinical use.
3

Levofloxacin and minocycline are guideline-supported primary alternatives to TMP-SMX, whereas tigecycline is increasingly used as salvage therapy for multidrug-resistant infections in intensive care settings.
4

The systematic review included 15 retrospective cohort studies, all of which received moderate- to high-quality Newcastle-Ottawa Scale scores.
5

Respiratory tract and bloodstream infections were the most frequently reported primary infection sites across the included cohorts.

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