Genomic landscape and molecular subtypes of primary central nervous system lymphoma

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Primary central nervous system lymphoma (PCNSL) is a rare and genetically heterogeneous subtype of non-Hodgkin lymphoma with poor prognosis.
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PCNSL is primarily composed of diffuse large B-cell lymphomas (DLBCLs), but it is biologically distinct from DLBCL.
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The study identified three molecular subtypes of PCNSL based on single-nucleotide variations, each linked to different clinical outcomes.
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Whole-exome sequencing was conducted on 140 newly diagnosed PCNSL patients to explore the genomic landscape and inform precision oncology.
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The applicability of existing DLBCL molecular classifications to PCNSL requires further validation due to significant molecular heterogeneity.

Blood Cancer Journal

by Shengjie Li, Danhui Li, Zuguang Xia, Jianing Wu, Jun Ren, Yingzhu Li, Jiazhen Cao, Ying Sun, Chengxun Li, Wenjun Cao, Ying Mao
November 26, 2025

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