Guiding immunotherapy based on the oxford classification activity score in IgA nephropathy - Takeaways - MDSpire

Guiding immunotherapy based on the oxford classification activity score in IgA nephropathy

  • By

  • Jingjing Nong

  • Yuhong Tang

  • Jiazhen Yang

  • Wenli Wei

  • Licong Su

  • Sheng Nie

  • Jun Ou

  • June 23, 2026

  • 0 min

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  • 1

    The study analyzed 2,389 patients with IgA nephropathy to evaluate the role of Oxford classification activity scores in immunotherapy management.

  • 2

    Immunotherapy was associated with a 22% increase in proteinuria remission at 12 months for patients with IgA nephropathy.

  • 3

    High SumMEC scores indicated a positive response to immunotherapy, while lower scores did not show the same benefit.

  • 4

    The Oxford classification system includes M, E, S, and T features, with recent studies suggesting the importance of M, E, and C lesions.

  • 5

    The study highlights the need for composite scoring systems like SumMEC to better assess immunotherapy responsiveness in IgA nephropathy.

Original Source(s)

Guiding immunotherapy based on the oxford classification activity score in IgA nephropathy

  • by Jingjing Nong, Yuhong Tang, Jiazhen Yang, Wenli Wei, Licong Su, Sheng Nie, Jun Ou

  • June 23, 2026

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