Dysregulation of U12-Type Splicing in Lupus Neutrophils - Takeaways - MDSpire

Alterations in U12-Type RNA Splicing in Neutrophils of Systemic Lupus Erythematosus Patients

  • By

  • Luz P. Blanco

  • Binod Regmi

  • Carmelo Carmona-Rivera

  • Yudong Liu

  • Xiantao Wang

  • Philip M. Carlucci

  • Monica M. Jackson

  • Zerai Manna

  • Sarfaraz Hasni

  • Markus Hafner

  • Hong-Wei Sun

  • Mariana J. Kaplan

  • July 1, 2026

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  • 1

    Aberrant RNA splicing is implicated in the pathogenesis of systemic lupus erythematosus (SLE), affecting immune gene regulation.

  • 2

    Neutrophils play a critical role in SLE through reactive oxygen species production and the formation of neutrophil extracellular traps.

  • 3

    Low-density granulocytes (LDGs) in SLE exhibit enhanced NET formation and mitochondrial ROS production, indicating a distinct pathogenic phenotype.

  • 4

    Impaired Nox activity in SLE LDGs is associated with reduced CYBA expression and U12 intron retention, suggesting minor spliceosome dysfunction.

  • 5

    Transcriptomic analysis reveals broad splicing abnormalities in SLE LDGs, particularly affecting U12-type introns, contributing to immune dysregulation.

Original Source(s)

Dysregulation of U12-Type Splicing in Lupus Neutrophils

  • by Luz P. Blanco, Binod Regmi, Carmelo Carmona-Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong-Wei Sun, Mariana J. Kaplan

  • July 1, 2026

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