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1
The study investigates the role of TCDD in psoriasis, focusing on its impact on immune dysregulation and treatment outcomes.
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2
Eighty-seven genes were identified that overlap between TCDD-related targets and psoriasis-associated genes, enriched in key signaling pathways.
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3
Five core target genes—LCK, MMP9, CXCR2, PTAFR, and CCNB1—were significantly upregulated in psoriatic lesions and linked to immune infiltration.
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4
Keratinocyte validation showed increased expression of LCK, MMP9, CXCR2, and PTAFR, while CCNB1 exhibited only modest changes.
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5
Baseline MMP9 levels were associated with treatment response in biologic-therapy cohorts, indicating potential relevance to clinical outcomes.
