Naloxone and Clinical Outcomes in Suspected Opioid-Associated Out-of-Hospital Cardiac Arrests - Takeaways - MDSpire

Naloxone and Clinical Outcomes in Suspected Opioid-Associated Out-of-Hospital Cardiac Arrests

  • By

  • Ralph C. Wang

  • Jake Toy

  • Juan Carlos C. Montoy

  • Juliana Tolles

  • Paul F. Ehlers

  • J Joelle Donofrio-Odmann

  • James J. Menegazzi

  • Marianne Gausche-Hill

  • Robert M. Rodriguez

  • David G. Dillon

  • CAL-ROC Investigators

  • John M VanBuren

  • Nichole Bosson

  • Dustin W Ballard

  • Amelia M Breyre

  • Senai Kidane

  • Zita Konik

  • Mark Luoto

  • Kevin Mackey

  • John S Rose

  • Shira Schlesinger

  • Alexander Schmalz

  • Daniel Sheperd

  • Pranav Shetty

  • Reza Vaezazizi

  • Sachin Agarwal

  • Ann Johnson

  • Roger J Lewis

  • Jason McMullan

  • Stephen Sanko

  • Manish I Shah

  • Hernando Garzon

  • Daniel Nishijima

  • Debbie Y Madhok

  • Mary P Mercer

  • Christopher J Coyne

  • Christopher A Kahn

  • May 29, 2026

  • 0 min

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  • 1

    Drug overdose deaths in the US peaked at 114,664 in 2023, with a significant rise in drug-related out-of-hospital cardiac arrests (OHCAs).

  • 2

    Naloxone administration by EMS in suspected opioid-associated OHCAs may improve survival outcomes, though evidence from clinical trials is lacking.

  • 3

    The study utilized data from the California Resuscitation Outcomes Consortium, analyzing naloxone's impact on survival in OHCA patients from 2021 to 2022.

  • 4

    Primary outcomes included survival to hospital discharge and favorable neurologic outcomes, with secondary outcomes assessing sustained return of spontaneous circulation.

  • 5

    The study aimed to clarify the association between naloxone use and survival in OHCA, addressing inconsistencies in previous research findings.

Original Source(s)

Naloxone and Clinical Outcomes in Suspected Opioid-Associated Out-of-Hospital Cardiac Arrests

  • by Ralph C. Wang, Jake Toy, Juan Carlos C. Montoy, Juliana Tolles, Paul F. Ehlers, J Joelle Donofrio-Odmann, James J. Menegazzi, Marianne Gausche-Hill, Robert M. Rodriguez, David G. Dillon, CAL-ROC Investigators, John M VanBuren, Nichole Bosson, Dustin W Ballard, Amelia M Breyre, Senai Kidane, Zita Konik, Mark Luoto, Kevin Mackey, John S Rose, Shira Schlesinger, Alexander Schmalz, Daniel Sheperd, Pranav Shetty, Reza Vaezazizi, Sachin Agarwal, Ann Johnson, Roger J Lewis, Jason McMullan, Stephen Sanko, Manish I Shah, Hernando Garzon, Daniel Nishijima, Debbie Y Madhok, Mary P Mercer, Christopher J Coyne, Christopher A Kahn

  • May 29, 2026

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