Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation - Takeaways - MDSpire

Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation

  • By

  • Tilman Schneider-Hohendorf

  • Christian Wünsch

  • Simon Falk

  • Catarina Raposo

  • Florian Rubelt

  • Hamid Mirebrahim

  • Hosseinali Asgharian

  • Ulrich Schlecht

  • Daniel Mattox

  • Wenyu Zhou

  • Eva Dawin

  • Marc Pawlitzki

  • Sarah Lauks

  • Sven Jarius

  • Brigitte Wildemann

  • Joachim Havla

  • Tania Kümpfel

  • Miriam-Carolina Schrot

  • Marius Ringelstein

  • Markus Kraemer

  • Carolin Schwake

  • Thomas Schmitter

  • Ilya Ayzenberg

  • Katinka Fischer

  • Sven G Meuth

  • Orhan Aktas

  • Martin W Hümmert

  • Julian R Kretschmer

  • Corinna Trebst

  • Ilka Kleffner

  • Jennifer Massey

  • Paolo A Muraro

  • Haiyin Chen-Harris

  • Catharina C Gross

  • Luisa Klotz

  • Heinz Wiendl

  • Nicholas Schwab

  • July 18, 2024

  • 0 min

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  • 1

    Epstein-Barr virus (EBV) infection is linked to multiple sclerosis (MS), with MS patients showing elevated EBV-specific antibodies and CNS damage post-infection.

  • 2

    MS patients exhibit a broader MHC-I-restricted EBV-specific T-cell receptor beta chain repertoire compared to healthy controls, indicating an altered immune response.

  • 3

    The study analyzed TRB repertoire samples from various patient groups, finding that only MS patients had a broader anti-EBV TRB repertoire.

  • 4

    MS therapies, such as ocrelizumab and teriflunomide, reduced EBV-specific T-cell responses, suggesting treatment impacts the EBV-related immune response.

  • 5

    The findings indicate that the aberrant T-cell response to EBV is specific to MS and may be influenced by therapies targeting EBV-infected cells.

Original Source(s)

Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation

  • by Tilman Schneider-Hohendorf, Christian Wünsch, Simon Falk, Catarina Raposo, Florian Rubelt, Hamid Mirebrahim, Hosseinali Asgharian, Ulrich Schlecht, Daniel Mattox, Wenyu Zhou, Eva Dawin, Marc Pawlitzki, Sarah Lauks, Sven Jarius, Brigitte Wildemann, Joachim Havla, Tania Kümpfel, Miriam-Carolina Schrot, Marius Ringelstein, Markus Kraemer, Carolin Schwake, Thomas Schmitter, Ilya Ayzenberg, Katinka Fischer, Sven G Meuth, Orhan Aktas, Martin W Hümmert, Julian R Kretschmer, Corinna Trebst, Ilka Kleffner, Jennifer Massey, Paolo A Muraro, Haiyin Chen-Harris, Catharina C Gross, Luisa Klotz, Heinz Wiendl, Nicholas Schwab

  • July 18, 2024

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