Impact of haematopoietic stem cell transplantation for benign and malignant haematologic and non-haematologic disorders on fertility: a systematic review and meta-analysis - Takeaways - MDSpire

Impact of haematopoietic stem cell transplantation for benign and malignant haematologic and non-haematologic disorders on fertility: a systematic review and meta-analysis

  • By

  • Angela Vidal

  • Cristina Bora

  • Andrea Jarisch

  • Janna Pape

  • Susanna Weidlinger

  • Tanya Karrer

  • Michael von Wolff

  • February 26, 2025

  • 0 min

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  • 1

    Haematopoietic stem cell transplantation (HSCT) is used for both malignant and benign disorders, with increasing indications and improved survival rates.

  • 2

    Infertility is a significant long-term complication of HSCT, with pregnancy rates reported to be less than 5% post-transplant.

  • 3

    Fertility preservation strategies are complex and vary based on the urgency of HSCT and prior gonadotoxic treatments.

  • 4

    The systematic review aims to assess gonadal toxicity from myoablative treatments to guide fertility preservation recommendations.

  • 5

    The study protocol is registered with PROSPERO, and inclusion criteria focus on original studies detailing fertility outcomes post-HSCT.

Original Source(s)

Impact of haematopoietic stem cell transplantation for benign and malignant haematologic and non-haematologic disorders on fertility: a systematic review and meta-analysis

  • by Angela Vidal, Cristina Bora, Andrea Jarisch, Janna Pape, Susanna Weidlinger, Tanya Karrer, Michael von Wolff

  • February 26, 2025

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