The glucose-6-phosphatase system in cancer: from endoplasmic reticulum glucose-6-phosphate flux to stemness, immune escape, and therapeutic vulnerability - Takeaways - MDSpire

The glucose-6-phosphatase system in cancer: from endoplasmic reticulum glucose-6-phosphate flux to stemness, immune escape, and therapeutic vulnerability

  • By

  • Bogdan Alexandru Danalache

  • Abdallah Fallah

  • Frédéric Mercier

  • Borhane Annabi

  • July 17, 2026

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  • 1

    The glucose-6-phosphatase (G6Pase) system regulates intracellular glucose-6-phosphate dynamics with implications for cancer biology.

  • 2

    Elevated G6Pase activity in non-gluconeogenic cancers is linked to aggressive tumor phenotypes and therapy resistance.

  • 3

    The G6Pase system components, including G6PC1-3 and SLC37A4, are emerging as potential biomarkers and therapeutic targets in cancer.

  • 4

    The system's role extends beyond glucose production, influencing redox control, calcium homeostasis, and protein quality control.

  • 5

    Clinical targeting of the G6Pase system is still in preclinical stages, with therapeutic opportunities requiring further investigation.

Original Source(s)

The glucose-6-phosphatase system in cancer: from endoplasmic reticulum glucose-6-phosphate flux to stemness, immune escape, and therapeutic vulnerability

  • by Bogdan Alexandru Danalache, Abdallah Fallah, Frédéric Mercier, Borhane Annabi

  • July 17, 2026

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