Case Report: Occult mantle cell lymphoma in a synchronous rectal collision tumor with adenocarcinoma: retrospective reclassification and multispecimen molecular profiling - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Retrospective Analysis of a Rare Collision Tumor: Mantle Cell Lymphoma Coexisting with Rectal Adenocarcinoma and Molecular Profiling of Multiple Specimens

  • By

  • Qing Zhang

  • Yingjie Xiu

  • Junhong Li

  • Xin Cao

  • August 20, 2026

Share

  • 1

    Collision tumors of colorectal adenocarcinoma and mantle cell lymphoma are rare, with limited molecular characterization of their components.

  • 2

    A 65-year-old woman developed mantle cell lymphoma after initial treatment for rectal adenocarcinoma, highlighting diagnostic challenges.

  • 3

    Molecular profiling revealed shared TP53 alterations in both adenocarcinoma and lymphoma components, indicating partial overlap.

  • 4

    The mantle cell lymphoma was initially undetected in the rectal resection specimen, only identified after systemic disease emerged.

  • 5

    The patient received treatment with bendamustine and rituximab, followed by zanubrutinib, and remained in remission at follow-up.

Original Source(s)

Case Report: Occult mantle cell lymphoma in a synchronous rectal collision tumor with adenocarcinoma: retrospective reclassification and multispecimen molecular profiling

  • by Qing Zhang, Yingjie Xiu, Junhong Li, Xin Cao

  • August 20, 2026

Related Content

Correction: Serial ctDNA dynamics predict clinical outcomes in metastatic and locally advanced PDAC: a systematic review

Matters arising in IJCD beyond minimally invasive pelvic exenteration: can single-port robotics overcome deep pelvic constraints?

National Cancer Institute–Supported Obesity and Cancer Research, 2015-2022