Effect of anti-anxiety therapy on the prognosis of patients with atrial fibrillation and anxiety: a 2 × 2 factorial randomized controlled trial

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The study evaluated the efficacy of combined anti-anxiety therapy in 120 patients with atrial fibrillation and anxiety using a 2 × 2 factorial design.
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Significant improvements in quality of life were observed in intervention groups compared to the control group at 6 months, with P values < 0.01.
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Factorial analysis revealed significant main effects for both psychological intervention and drug therapy, indicating additive benefits without significant interaction.
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The Combination group showed a significantly lower incidence of Major Adverse Cardiovascular Events at 6 months compared to the Control group (36.67% vs. 70.00%, P = 0.003).
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The study highlights the potential of integrating psychological care into atrial fibrillation management to improve patient outcomes.

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