The potential role of antimetabolite in preventing allosensitization before kidney retransplantation - Takeaways - MDSpire

The potential role of antimetabolite in preventing allosensitization before kidney retransplantation

  • By

  • Madeleine Thommen

  • Lukas Weidmann

  • Dusan Harmacek

  • Seraina von Moos

  • Florian Westphal

  • Kerstin Hübel

  • Britta George

  • Anna Mallone

  • Lukas Frischknecht

  • Jakob Nilsson

  • Thomas Schachtner

  • Elena Rho

  • July 8, 2026

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  • 1

    Retransplantation is increasingly common, with 16% of kidney transplants in the study being retransplantations.

  • 2

    The study analyzed factors affecting allosensitization in kidney retransplant recipients from 2012 to 2023.

  • 3

    Intake of antimetabolites was associated with lower calculated panel reactive antibodies (cPRA) at retransplantation.

  • 4

    Waiting time for deceased donations averaged 4 years, with a weak correlation to allosensitization levels.

  • 5

    The burden of immunosuppression decreased significantly from graft failure to retransplantation.

Original Source(s)

The potential role of antimetabolite in preventing allosensitization before kidney retransplantation

  • by Madeleine Thommen, Lukas Weidmann, Dusan Harmacek, Seraina von Moos, Florian Westphal, Kerstin Hübel, Britta George, Anna Mallone, Lukas Frischknecht, Jakob Nilsson, Thomas Schachtner, Elena Rho

  • July 8, 2026

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