Programmed cell death mechanisms of traditional plant medicine in prostate cancer therapy - Takeaways - MDSpire

Programmed cell death mechanisms of traditional plant medicine in prostate cancer therapy

  • By

  • Yuchen Zhang

  • Sheng Qin

  • Yingping Wang

  • Yajuan Xu

  • Yanzhu Zhu

  • July 14, 2026

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  • 1

    Prostate cancer (PCa) is a common malignancy in men, with significant mortality and treatment challenges due to resistance and recurrence.

  • 2

    Traditional plant medicines (TPM) have shown potential in inducing programmed cell death (PCD) and exhibiting anticancer activity against PCa.

  • 3

    The review identifies 42 drugs from TPM that regulate various forms of PCD, including apoptosis, ferroptosis, and necroptosis in PCa.

  • 4

    Key signaling pathways involved in TPM's anticancer effects include PI3K/AKT/mTOR and AMPK/mTOR, among others.

  • 5

    Further research is needed to clarify the effects of TPM on autophagy and pyroptosis in the context of PCa treatment.

Original Source(s)

Programmed cell death mechanisms of traditional plant medicine in prostate cancer therapy

  • by Yuchen Zhang, Sheng Qin, Yingping Wang, Yajuan Xu, Yanzhu Zhu

  • July 14, 2026

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