Characterization of JAK2V617F and the JAK2 46/1 germline haplotype in myeloproliferative neoplasms in a Saudi Arabian cohort: a case-based analysis - Takeaways - MDSpire

Analysis of JAK2V617F Mutation and JAK2 46/1 Germline Haplotype in Myeloproliferative Neoplasms Among a Saudi Arabian Population: A Case Study Approach

By
Nouf Mutrib
Sana Alqarni
Abdul Ali Peer-Zada
Manar Samman
Sabiha Fatima
Sadia Arjumand
Hala Aldahshan
Khalid K. Alharbi
May M. AlRashed
September 15, 2026

Frontiers In Oncology

Share

1

The study analyzed the prevalence of JAK2V617F mutations and the JAK2 46/1 haplotype in a Saudi Arabian cohort of myeloproliferative neoplasms.
2

A total of 130 participants were enrolled, including 98 patients with myeloproliferative neoplasms and 32 non-MPN controls.
3

JAK2V617F mutations were found in 13.1% of patients, with no significant difference in frequency between sexes.
4

The JAK2 46/1 haplotype was present in 80.7% of participants, indicating a potential inherited predisposition to myeloproliferative neoplasms.
5

This study is the first to characterize both JAK2V617F mutations and the JAK2 46/1 haplotype in a Saudi Arabian population.

Original Source(s)

Frontiers In Oncology

Characterization of JAK2V617F and the JAK2 46/1 germline haplotype in myeloproliferative neoplasms in a Saudi Arabian cohort: a case-based analysis

by Nouf Mutrib, Sana Alqarni, Abdul Ali Peer-Zada, Manar Samman, Sabiha Fatima, Sadia Arjumand, Hala Aldahshan, Khalid K. Alharbi, May M. AlRashed
September 15, 2026

Related Content

Jama Network Open

Cost-Effectiveness of Smoking Cessation Interventions Integrated Into Lung Cancer Screening

Frontiers In Immunology

Correction: Stem-like CD4 T cells in tumors: an emerging framework for antitumor immunity

by Jiaxiang Xu, Yunchao Yang, Jun Zhang, Yue Zhang
September 14, 2026

Journal Of Neuro-Oncology

Correction to: Anatomical and surgical factors associated with postoperative hydrocephalus after central neurocytoma resection: a large single-center cohort study