Pilot Results for Psilocybin-Assisted Psychotherapy for Cocaine Use Disorder—A Critical Appraisal

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Psilocybin-assisted therapy showed promise in improving cocaine-related outcomes over 180 days in a pilot study of 40 adults with cocaine use disorder.
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The study lacked fidelity monitoring and comprehensive reporting on secondary outcomes, raising concerns about the robustness of its findings.
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Contingency management is currently the most effective treatment for stimulant use disorders, contrasting with the challenges of implementing psilocybin therapy.
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Hendricks et al's study engaged more low-income and Black or African American participants, addressing limitations in prior psychedelic therapy trials.
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The exclusion of individuals with common comorbid conditions limits the applicability of psilocybin-assisted therapy for the broader population with cocaine use disorder.

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