Case Report: Pulmonary artery biopsy findings in a patient with a BMPR2 variant-associated pulmonary arterial hypertension - Takeaways - MDSpire

Case Report: Pulmonary artery biopsy findings in a patient with a BMPR2 variant-associated pulmonary arterial hypertension

  • By

  • Hongxia Wu

  • Li Guo

  • Weiya Wang

  • Faming Jiang

  • Ye Wang

  • July 1, 2026

  • 0 min

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  • 1

    A 47-year-old male with a BMPR2 variant presented with dyspnea and recurrent hemoptysis, confirmed as pulmonary arterial hypertension (PAH).

  • 2

    Right heart catheterization revealed a mean pulmonary artery pressure of 46 mmHg and a pulmonary vascular resistance of 10.75 Wood units.

  • 3

    Pulmonary artery biopsy showed foam cell accumulation and infiltration of immune cells, indicating inflammation and lipid metabolism dysregulation.

  • 4

    The biopsy was performed to exclude other diagnoses and provided insights into the pathology of BMPR2-associated PAH.

  • 5

    Targeted PAH therapy improved symptoms, and the patient experienced resolution of hemoptysis after bronchial artery embolization.

Original Source(s)

Case Report: Pulmonary artery biopsy findings in a patient with a BMPR2 variant-associated pulmonary arterial hypertension

  • by Hongxia Wu, Li Guo, Weiya Wang, Faming Jiang, Ye Wang

  • July 1, 2026

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