Evaluation of Radiation Therapy Protocols Before and After Biodegradable Hydrogel (SpaceOAR) Administration to Mitigate Rectal Toxicity in Prostate Cancer Patients Receiving Carbon Ion Radiotherapy - Takeaways - MDSpire

Evaluation of Radiation Therapy Protocols Before and After Biodegradable Hydrogel (SpaceOAR) Administration to Mitigate Rectal Toxicity in Prostate Cancer Patients Receiving Carbon Ion Radiotherapy

  • By

  • Hyun Jin Kim

  • Hojin Kim

  • Sunmi Kim

  • Wonseuk Jang

  • Jin Sung Kim

  • Hee Kyo Jeong

  • Jeong Hoon Jang

  • Seyjoon Park

  • Ik Jae Lee

  • April 20, 2026

  • 0 min

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  • 1

    Carbon ion radiotherapy (CIRT) is effective for prostate cancer but limited by rectal toxicity due to anatomical proximity.

  • 2

    SpaceOAR hydrogel significantly reduces rectal radiation dose in patients receiving CIRT, improving treatment safety.

  • 3

    The study involved 25 prostate cancer patients who underwent SpaceOAR insertion prior to CIRT treatment.

  • 4

    Plans with SpaceOAR showed improved dosimetry and plan quality, as evidenced by dose-volume histograms and ProKnow scores.

  • 5

    Integrating SpaceOAR with CIRT allows for potential dose escalation to the target volume without compromising safety.

Original Source(s)

Evaluation of Radiation Therapy Protocols Before and After Biodegradable Hydrogel (SpaceOAR) Administration to Mitigate Rectal Toxicity in Prostate Cancer Patients Receiving Carbon Ion Radiotherapy

  • by Hyun Jin Kim, Hojin Kim, Sunmi Kim, Wonseuk Jang, Jin Sung Kim, Hee Kyo Jeong, Jeong Hoon Jang, Seyjoon Park, Ik Jae Lee

  • April 20, 2026

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