Integrative bioinformatics analysis identifies placental senescence-associated signatures in early-onset preeclampsia - Takeaways - MDSpire

Integrative bioinformatics analysis identifies placental senescence-associated signatures in early-onset preeclampsia

  • By

  • Li Lin

  • Ying Chen

  • Lei Chen

  • Shengyi Gu

  • Yao Lai

  • Xiang Li

  • Jing Peng

  • Xiaolin Hua

  • July 8, 2026

  • 0 min

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  • 1

    Early-onset preeclampsia (EOPE) is a severe hypertensive disorder linked to preterm delivery and maternal multi-organ dysfunction.

  • 2

    The study identified 44 senescence-related differentially expressed genes in EOPE placentas, primarily involved in cell proliferation pathways.

  • 3

    Hub genes LEP, ENG, MIF, and CYBB were predominantly expressed in trophoblasts and immune cells in EOPE.

  • 4

    Single-cell RNA sequencing revealed that senescence-associated activity was enriched in the trophoblast lineage.

  • 5

    The findings suggest a close relationship between placental senescence and the pathogenesis of EOPE.

Original Source(s)

Integrative bioinformatics analysis identifies placental senescence-associated signatures in early-onset preeclampsia

  • by Li Lin, Ying Chen, Lei Chen, Shengyi Gu, Yao Lai, Xiang Li, Jing Peng, Xiaolin Hua

  • July 8, 2026

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