Distinct microbial mediators link diet to inflammation in Crohn’s disease and ulcerative colitis

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IBD patients exhibit lower diet quality and microbiome diversity, with Crohn's disease showing the lowest microbial diversity.
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Coffee and whole wheat bread reduce inflammation in Crohn's disease through short-chain fatty acid-producing taxa.
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Mediterranean-like, fibre-rich diets lower inflammatory markers in ulcerative colitis by enhancing microbial richness.
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Personalized dietary interventions targeting specific microbial taxa may complement medical therapy for IBD.
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Identified microbial pathways may serve as biomarkers for monitoring diet responsiveness in IBD patients.

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by Luis Mayorga, Arnau Noguera Segura, Laura Campderros, Marc Pons-Tarin, Zaida Soler, Sara Vega-Abellaneda, Gerard Serrano-Gomez, Claudia Herrera-deGuise, Virginia Robles-Alonso, Natalia Borruel, Chaysavanh Manichanh
June 1, 2026

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