Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt - Takeaways - MDSpire

Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt

  • By

  • Lu Tang

  • Xiqin Liu

  • Yuanyuan Li

  • Nanfang Pan

  • Jianyu Li

  • Jian Zhou

  • Benjamin Becker

  • Qiyong Gong

  • July 7, 2026

  • 0 min

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  • 1

    Nonsuicidal self-injury (NSSI) and suicide attempts (SA) are significant self-injurious behaviors with distinct neurofunctional characteristics.

  • 2

    The meta-analysis included 10 studies for NSSI and 16 studies for SA, revealing increased right amygdala activation in NSSI individuals.

  • 3

    No significant activation differences were found between SA individuals and controls, although some increased activation was noted at a less conservative threshold.

  • 4

    Subgroup analyses indicated that neurofunctional abnormalities in NSSI were primarily driven by adolescent cohorts.

  • 5

    The study highlights the need for age-tailored risk assessment and interventions for self-injurious behaviors.

Original Source(s)

Comparative meta-analysis of task-related functional brain abnormalities in nonsuicidal self-injury and suicide attempt

  • by Lu Tang, Xiqin Liu, Yuanyuan Li, Nanfang Pan, Jianyu Li, Jian Zhou, Benjamin Becker, Qiyong Gong

  • July 7, 2026

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