Unadjusted Confounding in the Association Between Clonal Hematopoiesis and Heart Failure After Cancer Therapy - Takeaways - MDSpire

Unadjusted Confounding in the Association Between Clonal Hematopoiesis and Heart Failure After Cancer Therapy

  • By

  • Shi-Jie Zhang

  • Guiying Gao

  • June 1, 2026

  • 0 min

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  • 1

    A significant association exists between clonal hematopoiesis of indeterminate potential (CHIP) and heart failure risk post-cancer therapy.

  • 2

    The study by Shyr et al. adjusted for several factors but did not account for diabetes, HIV, obesity, chronic kidney disease, and cirrhosis.

  • 3

    The absence of adjustment for these confounders limits the robustness and causal interpretability of the findings.

  • 4

    E-value sensitivity analyses indicated that an unadjusted confounder with a strength of 1.83 could nullify the reported association.

  • 5

    The E-value of 1.83 is lower than the strength of associations for adjusted covariates, suggesting potential bias from unadjusted confounding.

Original Source(s)

Unadjusted Confounding in the Association Between Clonal Hematopoiesis and Heart Failure After Cancer Therapy

  • by Shi-Jie Zhang, Guiying Gao

  • June 1, 2026

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