Comparison of clinical and laboratory characteristics of neuromyelitis optica spectrum disorder with or without anti-connective tissue antibodies: an 18-month cohort follow-up - Takeaways - MDSpire

Comparison of clinical and laboratory characteristics of neuromyelitis optica spectrum disorder with or without anti-connective tissue antibodies: an 18-month cohort follow-up

  • By

  • Shuna Shi

  • Yang Liu

  • Zhenling Fu

  • Junzhe Yang

  • Zhengyu Sun

  • Haiyang Luo

  • Limei Wang

  • Yuming Xu

  • June 19, 2026

  • 0 min

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  • 1

    The study evaluated 205 AQP4-IgG-positive NMOSD patients to assess the impact of anti-connective tissue antibodies on clinical features.

  • 2

    Among the patients, 52.7% tested positive for anti-connective tissue antibodies, showing significant differences in laboratory results.

  • 3

    CTD abs+ patients had higher lymphocyte counts, monocyte-to-lymphocyte ratios, CSF white blood cell counts, and immunoglobulin levels.

  • 4

    CTD abs+ patients exhibited higher Expanded Disability Status Scale scores and annualized relapse rates during the 18-month follow-up.

  • 5

    The presence of CTD abs did not predict earlier relapses but was associated with a more severe inflammatory profile in NMOSD.

Original Source(s)

Comparison of clinical and laboratory characteristics of neuromyelitis optica spectrum disorder with or without anti-connective tissue antibodies: an 18-month cohort follow-up

  • by Shuna Shi, Yang Liu, Zhenling Fu, Junzhe Yang, Zhengyu Sun, Haiyang Luo, Limei Wang, Yuming Xu

  • June 19, 2026

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