Combination of Narrow-Margin Hepatectomy and External Beam Radiotherapy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis - Takeaways - MDSpire

Combination of Narrow-Margin Hepatectomy and External Beam Radiotherapy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

  • By

  • Tingli Lu

  • Yaqiong Wang

  • Boyu Chen

  • Weida Meng

  • Hai Huang

  • December 27, 2025

  • 0 min

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  • 1

    Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with a high postoperative recurrence rate after hepatectomy.

  • 2

    Narrow-margin hepatectomy is often performed to preserve healthy liver tissue, but it is associated with a high rate of local recurrence.

  • 3

    External beam radiotherapy (EBRT) has shown promise in treating HCC, potentially reducing local recurrence and improving prognosis.

  • 4

    This systematic review and meta-analysis aims to evaluate the effectiveness and safety of combining EBRT with narrow-margin hepatectomy for HCC.

  • 5

    The study adheres to PRISMA guidelines and includes strict eligibility criteria for assessing the outcomes of the combined treatment.

Original Source(s)

Combination of Narrow-Margin Hepatectomy and External Beam Radiotherapy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

  • by Tingli Lu, Yaqiong Wang, Boyu Chen, Weida Meng, Hai Huang

  • December 27, 2025

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