A case report of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with literature review - Takeaways - MDSpire

A case report of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with literature review

  • By

  • Dehui Kong

  • Man Yang

  • Xie Deng

  • ZiFan Xu

  • Hongqiong Duan

  • Guoqing Pan

  • Zi Lei

  • June 2, 2026

  • 0 min

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  • 1

    Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare tumor with histological features similar to papillary thyroid carcinoma.

  • 2

    Common clinical presentations of TL-LGNPPA include nasal obstruction, nasal bleeding, and rhinorrhea, but some cases are asymptomatic.

  • 3

    Histological examination reveals typical papillary and ductal structures, with a fibrous vascular axis and mild to moderate nuclear atypia.

  • 4

    Immunohistochemical analysis shows that TL-LGNPPA expresses TTF-1 and CK, while TG is mostly negative, with a Ki-67 index generally ≤10%.

  • 5

    Accurate diagnosis of TL-LGNPPA requires comprehensive histological assessment, immunohistochemical analysis, and imaging studies.

Original Source(s)

A case report of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with literature review

  • by Dehui Kong, Man Yang, Xie Deng, ZiFan Xu, Hongqiong Duan, Guoqing Pan, Zi Lei

  • June 2, 2026

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