AI-Powered Resting 12-Lead Electrocardiogram Algorithm for Predicting Low Peak Oxygen Consumption: Development and Validation Study

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Low peak oxygen consumption (peak V̇O2) is linked to increased cardiovascular disease risk and lower quality of life.
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The study aimed to develop an AI-enhanced algorithm using resting 12-lead ECG to predict low peak V̇O2.
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Data from two hospitals over 13 years were analyzed, including 832 training and 242 validation datasets.
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Low peak V̇O2 was defined as <14 mL/kg/min, indicating significantly impaired cardiorespiratory fitness.
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The study utilized wavelet transform for effective analysis of ECG signals in predicting low peak V̇O2.

Jmir Medical Informatics

by Shu-Chun Huang, Tieh-Cheng Fu, Michelle Liou, Yu-Chieh Huang, Sing-Ya Chang, Guan-Yi Huang, Hong-Ren Su
June 11, 2026

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