Neutrophil in sepsis: functional aberration and regulated cell death - Takeaways - MDSpire

Neutrophil in sepsis: functional aberration and regulated cell death

  • By

  • Li Liu

  • Yanli Yang

  • Haixia Yang

  • Meng Yang

  • June 5, 2026

  • 0 min

Share

  • 1

    Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated immune response to infection.

  • 2

    Neutrophils play a critical role in sepsis, exhibiting functional abnormalities and altered cell death pathways that contribute to immune dysfunction.

  • 3

    Inhibition of neutrophil apoptosis and activation of cell death pathways like necroptosis and pyroptosis exacerbate inflammation in sepsis.

  • 4

    Recent research has identified novel neutrophil subpopulations that significantly influence sepsis pathology and outcomes.

  • 5

    Targeting neutrophil function and programmed cell death presents new therapeutic strategies to improve sepsis treatment and reduce mortality.

Original Source(s)

Neutrophil in sepsis: functional aberration and regulated cell death

  • by Li Liu, Yanli Yang, Haixia Yang, Meng Yang

  • June 5, 2026

Related Content

Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study

False-positive beta-glucan test due to beta-glucan component in sterile gauze during treatment of fungal sepsis: a case report

Integrated multi-omics deciphers sepsis immune dysregulation: a dual-pathway targeted small-molecule therapy improves survival and ameliorates multi-organ dysfunction