Macronutrients tested in weight loss

Investigators compared cardiometabolic responses to matched weight loss across ketogenic, Mediterranean, and plant-forward diets.

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The study compared very-low-carbohydrate ketogenic, Mediterranean, and very-low-fat plant-forward diets in participants with obesity and prediabetes.
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Participants achieved approximately 10% weight loss across all diet groups, with high dietary adherence exceeding 95%.
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Hepatic insulin sensitivity increased significantly more in the ketogenic diet group compared to the Mediterranean and plant-forward diets.
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Prediabetes remission rates were 50%, 29%, and 7% for the ketogenic, Mediterranean, and plant-forward diets, respectively.
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The study's limitations included a small sample size, which may have affected the detection of between-group differences.

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