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1
Approximately two-thirds of ARDS patients exhibit spontaneous breathing during the early phase, either under mandatory or fully spontaneous ventilation.
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2
Preserving spontaneous breathing in ARDS may prevent secondary lung injury, improve hemodynamics, and reduce sedation and ICU stay duration.
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3
Spontaneous breathing can lead to patient self-inflicted lung injury (P-SILI) if inspiratory effort exceeds safe limits, particularly in collapsed lung areas.
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4
Emerging evidence suggests that mechanical ventilation can modulate and monitor inspiratory effort during the transition phase of ARDS.
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5
Spontaneous breathing may confer systemic benefits, including reduced need for deep sedation and lower risk of delirium, though evidence remains uncertain.
