Epigenetics of bipolar disorder: a bibliometric landscape and visualization analysis - Takeaways - MDSpire
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Epigenetic Factors in Bipolar Disorder: A Bibliometric Overview and Visualization Study

  • By

  • Lan Xiong

  • Haixia Fan

  • Jie Gao

  • Minmin Lei

  • June 5, 2026

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  • 1

    Bipolar disorder (BD) has a global prevalence of 1.5% and is associated with high mortality rates, particularly due to suicide.

  • 2

    Epigenetic mechanisms, including DNA methylation and non-coding RNA regulation, significantly influence the pathogenesis of BD.

  • 3

    A total of 1154 publications were analyzed, revealing the United States as the leading contributor to epigenetic BD research.

  • 4

    Key research themes include histone modifications, HDAC inhibitors, and the role of long noncoding RNAs in BD.

  • 5

    The study highlights a shift towards exploring dynamic regulatory networks and multi-omics integration in BD research.

Original Source(s)

Epigenetics of bipolar disorder: a bibliometric landscape and visualization analysis

  • by Lan Xiong, Haixia Fan, Jie Gao, Minmin Lei

  • June 5, 2026

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