Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy Improves Survival in Unresectable Esophageal Cancer: a systematic review, meta-analysis, and network meta-analysis - Takeaways - MDSpire

Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy Improves Survival in Unresectable Esophageal Cancer: a systematic review, meta-analysis, and network meta-analysis

  • By

  • Fan, Xuefei

  • Liu, Xin

  • Song, Mi

  • Yang, Yunxin

  • Li, Chenggong

  • Zhang, Jiandong

  • Hu, Pingping

  • April 27, 2026

  • 0 min

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  • 1

    Induction immunochemotherapy combined with concurrent chemoradiotherapy significantly improves overall survival in unresectable esophageal cancer.

  • 2

    CCRT plus consolidation immunotherapy enhances overall survival compared to CCRT alone, but not as significantly as ICT-CCRT.

  • 3

    Progression-free survival is consistently improved with CCRT plus consolidation immunotherapy compared to CCRT alone.

  • 4

    Induction immunochemotherapy ranks highest for both overall survival and progression-free survival in network meta-analysis.

  • 5

    There is a lack of randomized controlled trials to confirm the efficacy and optimal sequencing of these treatment strategies.

Original Source(s)

Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy Improves Survival in Unresectable Esophageal Cancer: a systematic review, meta-analysis, and network meta-analysis

  • by Fan, Xuefei , Liu, Xin , Song, Mi , Yang, Yunxin , Li, Chenggong , Zhang, Jiandong , Hu, Pingping

  • April 27, 2026

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