Case Report: Atypical pattern of pathologic response in cutaneous transdifferentiated melanoma with rhabdomyoblastic differentiation following neoadjuvant therapy - Takeaways - MDSpire

Case Report: Atypical pattern of pathologic response in cutaneous transdifferentiated melanoma with rhabdomyoblastic differentiation following neoadjuvant therapy

  • By

  • Isabela Paulino Serur

  • Beatriz Mendes Awni Cidale

  • Ana Zélia Leal Pereira

  • Gustavo Benfatti Olivato

  • Giulia Kodja Zanetta

  • Melissa Lissae Fugimori

  • Claudia Regina Gomes Cardim Mendes de Oliveira

  • Maria Fernanda Hunziker

  • Frederico José Ribeiro Teixeira Júnior

  • Rodrigo Ramella Munhoz

  • May 4, 2026

  • 0 min

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  • 1

    Transdifferentiated melanoma exhibits phenotypic plasticity, losing melanocytic markers while acquiring features from other tissue lineages.

  • 2

    A rare case of melanoma with rhabdomyosarcomatous differentiation was reported, presenting significant diagnostic challenges.

  • 3

    Neoadjuvant immunotherapy with ipilimumab and nivolumab led to a mixed metabolic response and complete regression of the melanocytic component.

  • 4

    The remaining high-grade rhabdomyoblastic component showed high proliferative activity and loss of melanocytic markers post-treatment.

  • 5

    This case highlights the need for integrated histopathological and molecular assessments to understand unique pathological responses in melanoma.

Original Source(s)

Case Report: Atypical pattern of pathologic response in cutaneous transdifferentiated melanoma with rhabdomyoblastic differentiation following neoadjuvant therapy

  • by Isabela Paulino Serur, Beatriz Mendes Awni Cidale, Ana Zélia Leal Pereira, Gustavo Benfatti Olivato, Giulia Kodja Zanetta, Melissa Lissae Fugimori, Claudia Regina Gomes Cardim Mendes de Oliveira, Maria Fernanda Hunziker, Frederico José Ribeiro Teixeira Júnior, Rodrigo Ramella Munhoz

  • May 4, 2026

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