Association of APOBEC mutagenesis with stromal and endothelial niche remodeling and PCDH9-linked signaling alterations in colorectal cancer - Takeaways - MDSpire

Association of APOBEC mutagenesis with stromal and endothelial niche remodeling and PCDH9-linked signaling alterations in colorectal cancer

  • By

  • Junting Chen

  • Jiaming Cao

  • Baosen Zhou

  • Lianshuang Zhao

  • Chang Zheng

  • July 16, 2026

Share

  • 1

    APOBEC cytidine deaminases contribute to TCW-context mutations, impacting colorectal cancer progression and tumor microenvironment.

  • 2

    An APOBEC activation–associated transcriptional signature (AAS) identifies a colorectal cancer subtype with worse survival outcomes.

  • 3

    High AAS tumors exhibit stromal remodeling, increased fibroblast and endothelial signatures, and reduced cytotoxic immune infiltration.

  • 4

    Single-cell analyses reveal high AAS tumors are enriched for endothelial states with arterial and pro-angiogenic features.

  • 5

    Integrative analyses link PCDH9 to APOBEC-associated signaling alterations, suggesting its role in colorectal cancer evolution.

Original Source(s)

Association of APOBEC mutagenesis with stromal and endothelial niche remodeling and PCDH9-linked signaling alterations in colorectal cancer

  • by Junting Chen, Jiaming Cao, Baosen Zhou, Lianshuang Zhao, Chang Zheng

  • July 16, 2026

Related Content

Research progress of small molecule targeted drugs for non-small cell lung cancer

Circular RNA circEVI5 functions as a miR-433 sponge to promote renal cell carcinoma progression via GBP2-mediated oncogenic signaling

Quantitative assessment of inter-observer consistency in target volume delineation following breast-conserving surgery and mastectomy