Bacteriological Characteristics of Early-Onset Compared to Late-Onset Neonatal Sepsis in a Tertiary Care Facility in Nepal

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Neonatal sepsis is classified into early-onset and late-onset, with EONS occurring within 72 hours and LONS between 72 hours and 28 days after birth.
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Common risk factors for EONS include maternal infections, low birth weight, and prolonged rupture of membranes, while LONS is influenced by hygiene practices.
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The study analyzed 120 blood samples from neonates suspected of sepsis at Tribhuvan University Teaching Hospital in Nepal.
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Escherichia coli and Group B Streptococci are the primary causative agents of EONS, while Klebsiella pneumoniae and Staphylococcus aureus are common in LONS.
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Antibiotic susceptibility testing revealed patterns of resistance, including the detection of multidrug-resistant organisms among the isolates.

Bmc Infectious Diseases

by Rabita Karanjit, Sangita Sharma, Shyam Kumar Mishra, Hari Prasad Kattel, Sagun Suwal, Sujata Baidya, Sunita Makaju, Sajal Twanabasu
January 23, 2026

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