Immune-dominated cellular heterogeneity and stromal plasticity in keloid infiltrating and hypercellular zones revealed by single-cell RNA sequencing - Takeaways - MDSpire

Immune-dominated cellular heterogeneity and stromal plasticity in keloid infiltrating and hypercellular zones revealed by single-cell RNA sequencing

  • By

  • Yuchen Cao

  • Li Duan

  • Dongxian Lin

  • Yue Liu

  • Mingzi Yang

  • Shunbing Lu

  • Yonghao Liu

  • Yuanyuan Xu

  • Lianzhao Wang

  • June 26, 2026

  • 0 min

Share

  • 1

    Keloids are fibroproliferative disorders with spatial heterogeneity, characterized by a sclerotic core and an actively invading margin.

  • 2

    Single-cell RNA sequencing was performed on 128,678 cells from keloid samples to analyze cellular composition and interactions.

  • 3

    The hypercellular zone was dominated by myofibroblasts, while the infiltrating zone had more mononuclear phagocytes and endothelial cells.

  • 4

    Infiltrating zone fibroblasts exhibited an immunomodulatory phenotype, indicating a chronic inflammatory state with autoimmune features.

  • 5

    This study suggests a shift in understanding keloid pathogenesis from a fibroblast-centric model to an immune-driven landscape.

Original Source(s)

Immune-dominated cellular heterogeneity and stromal plasticity in keloid infiltrating and hypercellular zones revealed by single-cell RNA sequencing

  • by Yuchen Cao, Li Duan, Dongxian Lin, Yue Liu, Mingzi Yang, Shunbing Lu, Yonghao Liu, Yuanyuan Xu, Lianzhao Wang

  • June 26, 2026

Related Content

ERYXSeg: a hybrid CNN architecture for robust and resource-aware wound segmentation

Reducing medication burden and improving pressure injury outcomes in older emergency patients: a pharmacist-nurse collaboration

Case Report: Eyebrow pilonidal sinus with bridging scar