Pharmacotherapy, acupoint stimulation, and psychotherapy for perimenopausal women with anxiety, depression, and panic disorder: a systematic review and network meta-analysis of randomized controlled trials

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Perimenopausal women often experience anxiety, depression, and panic disorders due to hormonal changes and declining ovarian function.
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This network meta-analysis included 131 RCTs with 11,457 perimenopausal women to compare pharmacotherapy, AcuStim, and psychotherapy.
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Combination therapies generally showed more favorable efficacy across psychological and endocrine outcomes than single-modality interventions.
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Pharmacotherapy, acupoint stimulation, and psychotherapy each demonstrated therapeutic benefits for emotional disorders in perimenopausal women.
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No single treatment strategy was consistently superior across all outcomes, indicating the need for individualized treatment selection.

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