Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis - Takeaways - MDSpire

Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis

  • By

  • Zeyu Liang

  • Xiaoli Zhu

  • Yulan Chen

  • Ayiguzaili Maimaitimin

  • Nayiman Nihemaiti

  • Gulixian Shata

  • Rehanguli Maihemutijiang

  • June 16, 2026

  • 0 min

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  • 1

    The study assessed the relationship between the TyG index and body fat distribution metrics with CHD and MACE risk in adults with OSAHS.

  • 2

    TyG-WWI demonstrated the strongest association with prevalent CHD, with an odds ratio of 3.21 per 1-standard deviation increase.

  • 3

    Adding TyG-WWI to conventional risk factors significantly improved CHD discrimination, achieving an area under the curve of 0.802.

  • 4

    During a median follow-up of 17 months, TyG-WWI was also strongly associated with incident MACE, showing a hazard ratio of 1.545.

  • 5

    The findings suggest TyG-WWI may serve as a valuable marker for cardiovascular risk stratification in OSAHS patients.

Original Source(s)

Association of the TyG index and its body fat distribution composites with CHD and MACE risk in adults with OSAHS: incremental discrimination and exploratory mediation analysis

  • by Zeyu Liang, Xiaoli Zhu, Yulan Chen, Ayiguzaili Maimaitimin, Nayiman Nihemaiti, Gulixian Shata, Rehanguli Maihemutijiang

  • June 16, 2026

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