Enrichment of Immature CD10low Neutrophils in Individuals Diagnosed with Multiple Sclerosis - Takeaways - MDSpire

Enrichment of Immature CD10low Neutrophils in Individuals Diagnosed with Multiple Sclerosis

  • By

  • Luke W. Garratt

  • Alice A. White

  • Craig Schofield

  • Jonatan Leffler

  • Prue H. Hart

  • Marzena J. Fabis-Pedrini

  • Allan G. Kermode

  • Anne Brüstle

  • Stephanie Trend

  • April 29, 2026

  • 0 min

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  • 1

    CD10low neutrophils are significantly enriched in individuals with clinically isolated syndrome and multiple sclerosis compared to healthy controls.

  • 2

    These CD10low neutrophils exhibit decreased expression of CD16 and CD11b, indicating they are an immature neutrophil population.

  • 3

    The study utilized flow cytometry to analyze neutrophil phenotypes in the peripheral blood of participants with MS and controls.

  • 4

    Findings suggest that immature CD10low neutrophils may play a role in the pathology of active multiple sclerosis.

  • 5

    The research highlights the need for further investigation into neutrophil subpopulations as potential biomarkers for MS.

Original Source(s)

Enrichment of Immature CD10low Neutrophils in Individuals Diagnosed with Multiple Sclerosis

  • by Luke W. Garratt, Alice A. White, Craig Schofield, Jonatan Leffler, Prue H. Hart, Marzena J. Fabis-Pedrini, Allan G. Kermode, Anne Brüstle, Stephanie Trend

  • April 29, 2026

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