Upfront intensive chemo-immunotherapy with autograft in 199 adult mantle cell lymphoma patients: prolonged survival and cure potentiality at long term

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The study analyzed long-term outcomes of 199 adult mantle cell lymphoma patients treated with intensive chemo-immunotherapy and autograft.
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Eighty-five percent of patients achieved complete or unconfirmed complete remission after the treatment program.
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The 7-year overall survival rate was 67%, with significant differences based on MIPI risk scores.
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Patients with low MIPI scores had better progression-free survival compared to those with intermediate-high or high-risk scores.
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Blastoid histology was associated with worse survival outcomes, highlighting the importance of histological classification in prognosis.

Bone Marrow Transplantation

by Sergio Cortelazzo, Michael Mian, Andrea Evangelista, Liliana Devizzi, Paolo Corradini, Michele Magni, Marco Ladetto, Simone Ferrero, Andrea Rossi, Anna Maria Barbui, Caterina Patti, Alessandro Costa, Umberto Vitolo, Annalisa Chiappella, Fabio Benedetti, Andrés J. M. Ferreri, Paolo Nicoli, Luigi Rigacci, Claudia Castellino, Alessandro M. Gianni, Alessandro Rambaldi, Corrado Tarella
July 7, 2021

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